Medicinal Chemistry Consulting and Synthesis with Drug Discovery Expertise in Pain, Neurodegeneration, Oncology, Infection, Viral, and Metabolic Disorders.
Expert Witness Testimony in Legal Cases
Custom Synthesis of Reference Standards for Analytical Companies
Synthesis of Lead Molecules for Acadamic Researchers
IP Expansion for its Clients:
Novel functionalized 1,3-benzene diols and their method of use for the treatment of hepatic encephalopathy; Brenneman, Douglas E.; Kinney, William Alvin; McDonnell, Mark; Petkanas, Dean; PCT Int. Appl. (2015), WO 2015106108 A2 20150716.
Toxic aldehyde related diseases and treatment; Brady, Todd; Young, Scott; Kinney, William A.; PCT Int. Appl. (2014), WO 2014116836 A2 20140731.
Preparation of benzoxazole derivatives as novel traps in the treatment of macular degeneration; Chabala, John Clifford; Jordan, Thomas A.; Ling, Ke-Qing; Gleason, John G.; Kinney, William A.; PCT Int. Appl. (2014), WO 2014116593 A1 20140731.
Quinoline-derived peri-carbinols useful for treating, reducing a symptom of or reducing the risk of macular degeneration, and preparation thereof; Jordan, Thomas A.; Chabala, John Clifford; Ling, Ke-Qing; Kinney, William A.; From PCT Int. Appl. (2014), WO 2014100425 A1 20140626.
Novel PI3K p110 inhibitors and methods of use thereof; Katsikis, Peter D.; Kinney, William A.; Almond, Harold R.; Khan, Noshena; PCT Int. Appl. (2013), WO 2013090725 A1 20130620.
Examples are provided below of the types of projects:
Expert witness for a cases involving synthetic cannabinoids and patent disputes.
Inexpensively generate novel compounds for neuroprotection project at KannaLife Sciences, outsource their synthesis, build team of pharmacologists, and demonstrate improved biological properties.
Scale-up of Lead Compounds for academic researchers.
Design and synthesize tissue targeted drug for local Biotech company and overseeing crystallinity assessment studies for its development.
Devise practical synthetic pathway to avoid patented route and strategy for its GMP production.
Perform synthetic studies to determine the major human metabolite and provide reference materials for LC method development.
Provided IP landscape evaluation for Boston based Biotech Company, proposed new chemotypes to broaden patent portfolio, and monitored their synthesis.
Participate in Chemistry Advisory Board to evaluate medicinal chemistry progress and propose new molecules for synthesis.
Prepare drug discovery due diligence reports and research proposals for business development opportunities within major Pharmaceutical Company.